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  • Title: Efficient synthesis, structure, and antimicrobial activity of some novel N- and S-beta-D-glucosides of 5-pyridin-3-yl-1,2,4-triazoles.
    Author: Khalil NS.
    Journal: Carbohydr Res; 2006 Sep 25; 341(13):2187-99. PubMed ID: 16839524.
    Abstract:
    Glucosidation of some 4-amino- and 4-arylideneamino-5-(pyridin-3-yl)-2,4-dihydro-[1,2,4]-triazole-3-thiones with 2,3,4,6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide followed by chromatographic separation gave the corresponding N- and S-beta-D-glucosides. The structure of these two regiosiomers was established chemically and spectroscopically. Deamination as well as deacetylation of some selected nucleosides have been achieved. Antimicrobial screening of 14 selected compounds resulted in their activity against Aspergillus fumigatus, Penicillium italicum, Syncephalastrum racemosum, Candida albicans, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, and Escherichia coli.
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