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  • Title: The Salmonella enterica serovar Typhi Vi capsule and self-association pili share controls on expression.
    Author: Lee FK, Morris C, Hackett J.
    Journal: FEMS Microbiol Lett; 2006 Aug; 261(1):41-6. PubMed ID: 16842356.
    Abstract:
    Salmonella enterica serovar Typhi uses type IVB pili to facilitate eukaryotic cell invasion. Here, we compare environmental and genetic controls on pil operon transcription with those regulating viaB genes required for Vi antigen expression. Transcription of pil occurs only in the late logarithmic and stationary phases of bacterial growth while viaB expression occurs in the logarithmic growth phase. Expression of both viaB and pil was, however, optimal at 100 mM NaCl, and mutations in envZ/ompR, rcsB/rcsC, (but not rcsA), tviA, ihfB or fis affected transcription of both viaB and pil DNA. As both Vi antigen and Type IVB pili facilitate serovar Typhi invasion of human monocytes, an overlap of production controls is logical. It appears that Vi antigen synthesis precedes pilus production.
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