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  • Title: Soluble Dectin-1 as a tool to detect beta-glucans.
    Author: Graham LM, Tsoni SV, Willment JA, Williams DL, Taylor PR, Gordon S, Dennehy K, Brown GD.
    Journal: J Immunol Methods; 2006 Jul 31; 314(1-2):164-9. PubMed ID: 16844139.
    Abstract:
    Beta-glucans are structural components of fungal cell walls which are involved in the immune recognition of fungal pathogens and possess beneficial immunomodulatory activities in isolated form. Here we have developed a soluble chimeric form of the major mammalian beta-glucan receptor, Dectin-1, and demonstrate its application for the detection and characterisation of soluble and insoluble beta-glucans, including fungal particles, using ELISA, flow cytometric and fluorescence-based microscopy assays.
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