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  • Title: Development of Ki-1 lymphoma in a child suffering from multicentric reticulohistiocytosis.
    Author: Kuramoto Y, Iizawa O, Matsunaga J, Nakamura N, Tagami H.
    Journal: Acta Derm Venereol; 1991; 71(5):448-9. PubMed ID: 1684479.
    Abstract:
    We report a case of Ki-1 lymphoma that developed in a 16-year-old youth who had suffered from multicentric reticulohistiocytosis for 10 years. Over the past 3 years he had had a peculiar sclerosing lesion of the leg for which oral prednisone 5 mg daily was tried for one year, with a moderate effect. He developed a marked swelling of the inguinal lymphadenopathy on the same side as the affected leg lesion, which also developed a prominent swelling of the skin surrounding the sclerosed area. Immunohistochemical analysis of the lymph node biopsy revealed the features of Ki-1 lymphoma. This is the first case of association of multicentric reticulohistiocytosis with Ki-1 lymphoma.
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