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  • Title: Sudden death from pituitary apoplexy in a patient presenting with an isolated sixth cranial nerve palsy.
    Author: Warwar RE, Bhullar SS, Pelstring RJ, Fadell RJ.
    Journal: J Neuroophthalmol; 2006 Jun; 26(2):95-7. PubMed ID: 16845307.
    Abstract:
    A 68-year-old diabetic, hypertensive man presented with a left sixth cranial nerve palsy. MRI demonstrated an inhomogeneous sellar mass encroaching on the left cavernous sinus. Two days later, a left third cranial nerve palsy developed. Within 24 hours, the patient went into cardiac arrest and died. An autopsy showed hemorrhage within a pituitary macroadenoma ("pituitary apoplexy"). Pituitary apoplexy should be considered a cause of acute isolated sixth cranial nerve palsy and may represent a life-threatening emergency that can be averted with emergent hormonal replacement and hypophysectomy.
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