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  • Title: High incidence of familial breast cancer segregates with constitutional t(11;22)(q23;q11).
    Author: Wieland I, Muschke P, Volleth M, Röpke A, Pelz AF, Stumm M, Wieacker P.
    Journal: Genes Chromosomes Cancer; 2006 Oct; 45(10):945-9. PubMed ID: 16845657.
    Abstract:
    In a family with a high incidence of postmenopausal breast cancer and a case of glioblastoma, the constitutional translocation t(11;22)(q23;q11.2) was shown to segregate with the malignancies. The breakpoints in this family coincided with the common breakpoints in t(11;22) as shown by a translocation-specific PCR assay. Loss of heterozygosity analysis of breast tumor tissue revealed deletion of the normal chromosome 22, but retention of der(22) in the tumor cells, suggesting a predisposing effect of the der(22) for breast and brain tumor development in this family.
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