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  • Title: [Mechanisms of action of the stimulators of granulocytopoiesis under cytostatic myelosuppression conditions].
    Author: Gur'iantseva LA, Zhdanov VV, Udut EV, Simanina EV, Khrichkova TIu, Dygaĭ AM.
    Journal: Eksp Klin Farmakol; 2006; 69(2):44-7. PubMed ID: 16845940.
    Abstract:
    Mechanisms of action of pantogematogen (PG), granulocyte colony-stimulating factor (G-CSF), glycyram, and D-glucuronic asid (D-GA) have been investigated under the conditions of myelosuppression caused by the introduction of cyclophosphane. It is established that the activation of granulocytopoiesis by these preparations is based on various mechanisms: G-CSF directly stimulates the proliferation and differentiation of hemopoietic cells; PG enhances the proliferation of granulocytes due to activation of the regulatory systems; D-GA and glycyram normalize the structural and functional organization of a bone marrow, thus providing intensive maturing of the colony-forming units.
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