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  • Title: Application of high-performance liquid chromatography hyphenated techniques for identification of degradation products of cefpodoxime proxetil.
    Author: Fukutsu N, Kawasaki T, Saito K, Nakazawa H.
    Journal: J Chromatogr A; 2006 Oct 06; 1129(2):153-9. PubMed ID: 16846608.
    Abstract:
    Application of the HPLC hyphenated techniques of LC-MS, LC-NMR and solvent-elimination LC-IR was demonstrated by the identification of the degradation products of a third generation cephalosporin antibiotic, cefpodoxime proxetil, in solid state, drug formulation and solution. Molecular weight and fragment information were obtained by LC-MS, and detailed structural information was confirmed by LC-NMR. Information on the carboxyl functional group obtained by solvent-elimination LC-IR was useful for confirmation of the ester hydrolysis. The degradation products were successfully identified without complicated isolation or purification processes.
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