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  • Title: Correlation and cross-linking effects in imprinting sites for divalent adsorption in gels.
    Author: Stancil KA, Feld MS, Kardar M.
    Journal: J Phys Chem B; 2005 Apr 14; 109(14):6636-9. PubMed ID: 16851745.
    Abstract:
    We examine a method to mimic active sites in proteins by chemical imprinting of p-valent templates in heteropolymer gels. Previous studies have confirmed successful formation of sites by adsorption of targets with p >/= 2 contacts. We investigate the recovery of sites with p = 2 imprinted by lead methacrylate Pb(MAAc)(2) (placing two carboxyl groups in close proximity). The improved binding ability of gels with more cross-links, and the relative insensitivity to changes in gel volume contradict simple theory. We conclude that adsorber pairs are predominantly located on the same polymer chain, posing a challenge to mimicking protein-like function.
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