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  • Title: The slowing of Ca2+ signals by Ca2+ indicators in cardiac muscle.
    Author: Noble D, Powell T.
    Journal: Proc Biol Sci; 1991 Nov 22; 246(1316):167-72. PubMed ID: 1685242.
    Abstract:
    The use of high-affinity fluorescent probes for monitoring intracellular free Ca2+ in cardiac muscle is now widespread. We have investigated the consequences of introducing intracellular buffers with the properties of Fura-2 or Indo-1 on the action potential, Ca2+ transient and contractile activity of the myocardium. Our theoretical results suggest that, at the high intracellular concentrations of these fluorescent probes used on occasion to improve the signal-to-noise ratio of the emitted fluorescence, modulation of action potential profile and attenuation of the amplitudes of the Ca2+ transient and contraction can occur, together with subtle changes in the kinetics of these events.
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