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  • Title: Stereoisomers of the atypical neuroleptic carbidine modulate striatal dopamine release in awake rats.
    Author: Guinetdinov RR, Bogdanov MB, Pogorelov VM, Kudrin VS, Rayevsky KS.
    Journal: Neuropharmacology; 1991 Nov; 30(11):1251-4. PubMed ID: 1685561.
    Abstract:
    Intracerebral microdialysis was used to monitor extracellular levels of dopamine (DA), 3,4-dihydroxyphenylacetic acid and homovanillic acid in awake rats, after intraperitoneal administration of the cis- and trans-isomers (25 mg/kg and 1 mg/kg, respectively) of carbidine, the atypical neuroleptic drug, in comparison with sulpiride (50 mg/kg) and haloperidol (1 mg/kg). Trans-carbidine was found to be more potent than the cis-isomer in increasing the release of DA. In contrast to sulpiride and haloperidol, both isomers at the doses used, produced only a moderate elevation in the levels of the metabolites of DA. Transcarbidine seemed to be more potent as a neuroleptic drug, in comparison with the cis-isomer.
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