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  • Title: Correlation between plasma and urinary caffeine levels in preterm infants.
    Author: Cattarossi L, Violino M, Macagno F, Logreco P, Savoia M.
    Journal: J Perinat Med; 2006; 34(4):344-6. PubMed ID: 16856829.
    Abstract:
    BACKGROUND: We hypothesize that urine levels might be reliable to assess the therapeutic range of caffeine. OBJECTIVES: We correlated plasma and urinary levels of caffeine in preterm infants treated with this drug for apnea of prematurity. METHODS: Infants (n=56) were given a loading dose of caffeine citrate (10 mg/kg, per os) and 24 h later a maintenance dose (2 mg/kg, per os, once a day). Plasma and urinary levels of caffeine were determined 24 h after the loading dose (before administration of the maintenance dose) and then weekly. RESULTS: Plasma and urinary levels correlate at all examined ages: 29 weeks (r=0.92, P<0.001), 30 weeks (r=0.97, P<0.001), 31 weeks (r=0.82, P<0.001), 32 weeks (r=0.92, P<0.001), 33 weeks (r=0.87, P<0.001), 34 weeks (r=0.81, P<0.001). CONCLUSION: Urinary levels of caffeine might be a useful means to assess therapeutic ranges.
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