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  • Title: Platelet dysfunction contributes to the haemostatic defect in haemorrhagic fever with renal syndrome.
    Author: Cosgriff TM, Lee HW, See AF, Parrish DB, Moon JS, Kim DJ, Lewis RM.
    Journal: Trans R Soc Trop Med Hyg; 1991; 85(5):660-3. PubMed ID: 1685813.
    Abstract:
    To characterize further the nature of haemostatic impairment in haemorrhagic fever with renal syndrome, we assessed platelet function in 9 patients in whom the diagnosis was serologically confirmed. Defective platelet aggregation was demonstrated in every patient. An abnormality of the granule release reaction was demonstrated in all of 7 patients tested. Gel-filtered platelets from a normal subject showed normal aggregation in plasma from a patient with impaired aggregation, which is evidence for an intrinsic platelet defect, and against the presence of a circulating inhibitor in this patient.
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