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  • Title: [Do antihypertensive agents change the incidence of cardiovascular complications of hypertension?].
    Author: Himbert D, Paillole C, Dahan M, Steg PG, Laperche T, Gourgon R.
    Journal: Ann Cardiol Angeiol (Paris); 1991 Dec; 40(10):607-12. PubMed ID: 1685878.
    Abstract:
    The main aim of the treatment of hypertension is to reduce the incidence and severity of its complications. Despite some bias affecting the major clinical trials of diuretics and/or beta blockers, the results of the meta-analysis taking them into account demonstrate the effectiveness of the prevention of cerebrovascular complications and the less effective prevention of coronary complications. Progress can be hoped for as a result of new therapeutic categories (converting enzyme inhibitors, calcium channel inhibitors ...) and to a greater extent from new treatment strategies, involving better identification of "genuinely high risk" subjects.
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