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  • Title: [Sorcin overexpression and multidrug resistance in human gastric cancer cells].
    Author: Yi H, Yang YX, Tang CE, Chen ZC, Zhang GY, Xiao ZQ.
    Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2006 Jun; 31(3):340-4, 349. PubMed ID: 16859119.
    Abstract:
    OBJECTIVE: To screen multidrug resistance (MDR) related proteins in human gastric cancer using proteomics technique. METHODS: Two-dimensional electrophoresis (2-DE) was used to separate the total proteins of vincristine-resistant human gastric cancer cell line SGC7901/VCR and its counterpart SGC7901. PDQuest software was used to analyze 2-DE images, and the differential expression proteins between the 2 cell lines were identified by both MALDI-TOF-MS and ESI-Q-TOF. The differential expression level of sorcin, one of the identified proteins, was confirmed by western blot analysis. The effect of sorcin on the development of MDR of SGC7901/VCR was determined by antisense oligonucleotides (ASO) technique. RESULTS: Sorcin as a high expression protein in SGC7901/VCR was identified and the suppression of sorcin expression by sorcin ASO could enhance the vincristine chemosensitivity in SGC7901/VCR. CONCLUSION: Sorcin overexpression is related to MDR in human gastric cancer cell line SGC7901/VCR.
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