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  • Title: Ocular hypotensive activity of pirbuterol eye drops in rabbits.
    Author: Bonomi L, Perfetti S, Bellucci R, De Franco I.
    Journal: J Ocul Pharmacol; 1991; 7(3):191-4. PubMed ID: 1686050.
    Abstract:
    The IOP-lowering effect of pirbuterol, a beta-2 adrenergic agonist, was studied in rabbits. In normotensive rabbits, pirbuterol 0.5% eye drops reduced IOP by 20-25%. In ocular hypertensive rabbits (by glucose 5% venous infusion), pirbuterol reduced IOP by 20% (0.1% concentration) to 40% (0.5% and 1% concentration). A slight decrease in the effect was noticed after seven days of treatment.
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