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  • Title: Anti-inflammatory activity of Maytenus senegalensis root extracts and of maytenoic acid.
    Author: Sosa S, Morelli CF, Tubaro A, Cairoli P, Speranza G, Manitto P.
    Journal: Phytomedicine; 2007 Feb; 14(2-3):109-14. PubMed ID: 16860550.
    Abstract:
    Maytenus senegalensis (Lam.) Excell (Celastraceae) root extracts were investigated for their topical anti-inflammatory properties by measuring the inhibition of the Croton oil-induced ear oedema in mice. The highest anti-inflammatory activity was detected in the chloroform extract, which reduced the oedematous response with a potency similar to that of the NSAID reference drug indomethacin (ID(50)=84 and 93 microg/cm(2), respectively). Fractionation of the chloroform and of the hexane extracts led to the isolation of maytenoic acid (1), which exhibited a dose-dependent antiphlogistic effect (ID(50)=0.11 micromol/cm(2)) twice that of indomethacin (ID(50)=0.26 micromol/cm(2)) and only three times lower than that of hydrocortisone (ID(50)=0.04 micromol/cm(2)).
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