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  • Title: Structure-activity-relationship studies of conformationally restricted analogs of combretastatin A-4 derived from SU5416.
    Author: Pandit B, Sun Y, Chen P, Sackett DL, Hu Z, Rich W, Li C, Lewis A, Schaefer K, Li PK.
    Journal: Bioorg Med Chem; 2006 Oct 01; 14(19):6492-501. PubMed ID: 16860559.
    Abstract:
    A series of combretastatin A-4 analogs derived from the ATP competitive, VEGF receptor tyrosine kinase inhibitor, SU5416 were synthesized. The cytotoxic effects of the analogs were evaluated against PC-3 and MDA-MB-231 cancer cell lines, as well as their abilities to inhibit tubulin polymerization. Results are compared to those of compound 1, our lead compound previously reported.
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