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  • Title: Ventilatory response in the fetal lamb following peripheral chemodenervation.
    Author: Woodrum DE, Standaert TA, Parks CR, Belenky D, Murphy J, Hodson WA.
    Journal: J Appl Physiol Respir Environ Exerc Physiol; 1977 Apr; 42(4):630-5. PubMed ID: 16861.
    Abstract:
    Carotid infusions of sodium cyanide solution and perfusions of hypoxemic or hypercapnic fetal blood were done before and after peripheral chemoreceptor denervation. Step changes in PaO2 ranged from -11 to -22 Torr; step changes in PaCO2 ranged from +17 to +42 Torr. The cyanide dose was 0.2 mg/kg per loop system. Control perfusions consisted of 25 ml of fetal blood without changes in pH and blood gases. A ventilatory response occurred in the majority of all experimental perfusions regardless of innervation status of the peripheral chemoreceptors. No response occurred with control perfusions. There was a marked variability in the time of onset of ventilatory activity with a delay of greater than 10 s occurring following most perfusions. These studies demonstrate that the fetus has an attenuated ventilatory response to chemical stimuli and that hypoxia stimulates ventilation in the absence of peripheral chemoreceptors.
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