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  • Title: Association study of the glycogen synthase kinase-3beta gene polymorphism with prophylactic lithium response in bipolar patients.
    Author: Szczepankiewicz A, Rybakowski JK, Suwalska A, Skibinska M, Leszczynska-Rodziewicz A, Dmitrzak-Weglarz M, Czerski PM, Hauser J.
    Journal: World J Biol Psychiatry; 2006; 7(3):158-61. PubMed ID: 16861141.
    Abstract:
    A relationship between response to lithium prophylaxis and T-50C polymorphism of glycogen synthase kinase-3beta (GSK-3beta) gene was investigated in 89 bipolar patients (41 male and 48 female) who have been taking lithium for at least 5 years. The patients were delineated as excellent responders, partial responders and non-responders to lithium. The results obtained suggest that this polymorphism may not be related to the degree of prophylactic lithium response.
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