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  • Title: Selective inhibition of nicotinamide adenine dinucleotide dependent oxidations by substituted carbamides.
    Author: Ali B, Parmar SS, Dwivedi C, Harbison RD.
    Journal: Res Commun Chem Pathol Pharmacol; 1975 May; 11(1):163-6. PubMed ID: 168621.
    Abstract:
    Several 1-substituted acetyl-3-aryl carbamides selectively inhibited nicotinamide adenine dinucleotide (NAD) dependent oxidation of alpha-keotoglutarate and beta-hydroxybutyrate by rat brain homogenates. NAD-independent oxidation of succinate remained unaltered. The inhibition observed with 1-(N-acetylmorpholino)-3-(4-methylphenyl)carbamide was competitive in nature.
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