These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Ibopamine--pharmacologic principles].
    Author: Borchard U.
    Journal: Z Kardiol; 1991; 80 Suppl 8():63-6. PubMed ID: 1686693.
    Abstract:
    Ibopamine is the 3,4-diisobutyrylester of N-methyl-dopamine (epinine). Oral ibopamine is transferred during and after resorption (first-pass effect) to the active metabolite epinine by blood and tissue esterases. 200 mg ibopamine lead to maximal plasma concentrations of 60 to 100 nmol/l. The ratio of total epinine to free epinine is about 10:1. Epinine is intensively metabolized so that less than 1% of the oral dosage is eliminated via the kidneys. The plasma half-life of epinine amounts to about 45 min. Epinine activates dopamine (DA1, DA2)-, beta 1- and beta 2- as well as alpha-receptors. The affinity is of the other: DA1, DA2 greater than beta 1, beta 2 greater than alpha. Stimulation of postsynaptic DA1-receptors predominantly induces renal vasodilation and increase in diuresis. Stimulation of presynaptic DA2-receptors leads to a reduced liberation of noradrenaline (NA) from its presynaptic storage vesicles. This effects a decrease in NA-plasma concentration, peripheral resistance, and it is partly responsible for diuresis and natriuresis. Investigations in isolated organs have shown that the action on DA1, DA2-receptors occurs in the range of 100-700 nmol/l), whereas stimulation of beta 1- and beta 2-receptors affords significantly higher levels (affinity to human cardiac beta 1- and beta 2-receptors 5-10 mumol/l). alpha-receptors are only stimulated at still higher concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)
    [Abstract] [Full Text] [Related] [New Search]