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  • Title: [The experimental anti-arrhythmia properties of the histamine H1 receptor blockader fencarol].
    Author: Iakovlev GM, Skorobogatov VI, Svistov AS, Mironova MI.
    Journal: Farmakol Toksikol; 1991; 54(5):25-7. PubMed ID: 1686869.
    Abstract:
    Phencarol, a blocker of H1-histamine receptors, is used as an antihistaminic agent. The antiarrhythmic effect of phencarol was detected and studied on experimental models of arrhythmias in non-anesthetized rabbits in a dose of 5 mg/kg intravenously. The drug was shown to possess the pronounced antiarrhythmic and protective properties on the models of calcium-chloride-, adrenaline- and strophanthine-induced arrhythmias and to exert no influence on aconitine-induced arrhythmia. Phencarol was demonstrated to have no cardiodepressive effect.
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