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  • Title: [Differential contribution of dopamine D1 and D2 receptors in the mu-opioidergic immunomodulation].
    Author: Cheĭdo MA, Idova GV.
    Journal: Ross Fiziol Zh Im I M Sechenova; 2006 May; 92(5):546-51. PubMed ID: 16869283.
    Abstract:
    The study has shown that activation of mu-opioid receptors by a highly selective agonist DAGO (100 microg/kg) results in a significant increase of the immune response to antigen (SRBC, 5% 10(8)) in CBA mice. Haloperidol (2 mg/kg), a selective antagonist of the postsynaptic dopamine (DA) receptors, prevented immunostimulating effect of DAGO. In contrast, selective D1--antagonist SCH 23390 (1 mg/kg) did not affect on DAGO-induced enhancing of immune reactivity. At the same time, the blockade of both types of DA receptors (D1 and D2) caused similar immunosuppressing effects. These data suggest a possible differential role for D1 and D2 receptors in mu-opioidergic immunomodulation.
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