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  • Title: Identification of RFamide neuropeptides in the medicinal leech.
    Author: Evans BD, Pohl J, Kartsonis NA, Calabrese RL.
    Journal: Peptides; 1991; 12(5):897-908. PubMed ID: 1686933.
    Abstract:
    Using a four-step reverse phase HPLC separation and RIA, five RFamide peptides were purified from CNS extracts of the leech Hirudo medicinalis. YMRFamide, FMRFamide, YLRFamide, FLRFamide, and GGKYMRFamide were identified by a combination of antiserum specificity in RIA, Edman degradation, and mass spectrometry. At least three of these five endogenous peptides can modulate neuromuscular interactions in the leech (38). FMRFamide-like immunoreactivity was selectively released from neural processes on isolated heart tubes in the presence of calcium and depolarizing levels of potassium.
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