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  • Title: Direct-type catalytic three-component mannich reactions leading to an efficient synthesis of alpha,beta-diamino acid derivatives.
    Author: Salter MM, Kobayashi J, Shimizu Y, Kobayashi S.
    Journal: Org Lett; 2006 Aug 03; 8(16):3533-6. PubMed ID: 16869653.
    Abstract:
    [reaction: see text] The first example of the Lewis acid-catalyzed three-component direct-type Mannich reaction of simple aromatic and enolizable aliphatic aldehydes, secondary amines, and glycine derivatives is described. The procedure is highly atom economical and can be performed in a simple one-pot operation under mild conditions to afford a wide variety of synthetically important anti-alpha,beta-diamino ester derivatives in high yields with high diastereoselectivities.
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