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  • Title: Histiocytoid eccrine sweat gland carcinoma of the eyelid: report of a case.
    Author: Swinson B, Ryan F, Barrett AW, Jerjes W, Landon G, Calonje E, Kalavrezos N.
    Journal: Clin Exp Dermatol; 2006 Nov; 31(6):786-9. PubMed ID: 16869823.
    Abstract:
    This report describes the 12th documented case of histiocytoid, diffuse or signet-ring cell eccrine sweat gland carcinoma of the eyelid, a rare neoplasm that characteristically affects older men and mimics distant metastasis. Clinically, the patient was thought to have a colonic metastasis. Histologically, the neoplasm comprised sheets and cords of polygonal, eosinophilic cells, with dispersed larger, rounded single cells resembling histiocytes, and cells with cytoplasmic lumina or a signet-ring appearance. Occasional duct formation was also seen. The features were reminiscent of both the histiocytoid and lobular variants of breast carcinoma. Ultrastructurally, the presence of nonintestinal type microvilli with a length : width ratio in excess of 16 were consistent with an eccrine origin, but also raised the possibility of metastatic mesothelioma. However, a metastatic lesion was excluded by clinical and imaging investigations. There has been no recurrence 3 years after primary excision.
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