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  • Title: Pathogenic role of anti-C1q autoantibodies in the development of lupus nephritis--a hypothesis.
    Author: Flierman R, Daha MR.
    Journal: Mol Immunol; 2007 Jan; 44(1-3):133-8. PubMed ID: 16870257.
    Abstract:
    A substantial proportion of patients with systemic lupus erythematosus (SLE) develop renal inflammatory disease, so-called lupus nephritis (LN). LN is a severe complication of SLE which is strongly associated with the presence of autoantibodies against C1q, the first component of the complement system, and other self-antigens (i.e. against DNA and nucleosomes) as well. In this review, the authors focus on anti-C1q autoantibodies and interpret the available data in order to explain how LN may develop and how anti-C1q autoantibodies contribute to its pathogenesis.
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