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  • Title: Bupropion augmentation in the treatment of chronic fatigue syndrome with coexistent major depression episode.
    Author: Schönfeldt-Lecuona C, Connemann BJ, Wolf RC, Braun M, Freudenmann RW.
    Journal: Pharmacopsychiatry; 2006 Jul; 39(4):152-4. PubMed ID: 16871471.
    Abstract:
    While psychoeducational strategies and general support are always indicated for the treatment of chronic fatigue syndrome (CFS), pharmacological strategies are yet not well established. Antidepressants such as selective serotonin re-uptake inhibitors have been shown to influence positively symptoms and immunological parameters. However, a considerable part of CFS patients do not satisfactorily respond to them. Bupropion, a centrally acting catecholamine-transporter blocker without classic psycho-analeptic properties, shows theoretical potential to improve fatigue symptoms. In the reported case paroxetine was augmented with bupropion at high dosage, a strategy which consecutively led to a rapid relief of CFS-symptoms.
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