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  • Title: Stemoninines from the roots of Stemona tuberosa.
    Author: Lin LG, Zhong QX, Cheng TY, Tang CP, Ke CQ, Lin G, Ye Y.
    Journal: J Nat Prod; 2006 Jul; 69(7):1051-4. PubMed ID: 16872143.
    Abstract:
    Five new stemoninine-type alkaloids, bisdehydrostemoninine (1), isobisdehydrostemoninine (2), bisdehydroneostemoninine (3), and bisdehydrostemoninines A (4) and B (5), were isolated from the crude-alkaloid extract of the roots of Stemona tuberosa. Their structures were elucidated on the basis of one- and two-dimensional NMR and other spectroscopic studies. The relative configuration of 4 was determined by X-ray diffraction. Alkaloid 1 displayed significant antitussive activity in the citric acid-induced guinea pig cough model.
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