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  • Title: Polymorphonuclear cell function impairment in patients with Chlamydia trachomatis urogenital infections.
    Author: Monno R, Vena G, Cafforio P, Milone E.
    Journal: Acta Microbiol Hung; 1991; 38(1):75-9. PubMed ID: 1687344.
    Abstract:
    The phagocytic and killing functions of polymorphonuclear cells (PMNs) and monocytes in patients with culturally and serologically proven Chlamydia trachomatis urogenital infections, and the distribution of peripheral blood T cell subsets in the same patients were analysed. A significant impairment of PMNs function was observed in infected patients as compared to the control group, whereas the monocyte function was not affected. In addition, a decrease of CD4+ cells frequency was observed in these patients. Since the PMNs are the most prominent cells observed at the site of C. trachomatis infection, we suggest that a defect of PMNs function may play a role in the host susceptibility to C. trachomatis.
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