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  • Title: A new enzyme, NADPH-dihydropteridine reductase in bovine liver.
    Author: Nakanishi N, Hasegawa H, Watabe S.
    Journal: J Biochem; 1977 Mar; 81(3):681-5. PubMed ID: 16875.
    Abstract:
    An enzyme designated as NADPH-dihydropteridine reductase was found in the extract of bovine liver and partially purified. In contrast to NADH-dpendent dihydropteridine reductase [EC 1.6.99.7], the enzyme catalyzes the reduction of quinonid-dihydropterin to tetrahydropterin in the presence of NADPH. The two enzymes were separated by column chromatography on DEAE-sephadex. Tyrosine formation in the phenylalanine hydroxylation system was also stimulated by NADPH-dihydropteridine reductase. The existence of these two dihydropteridine reductases suggests that the tetrahydro from ofpteridine cofactor may be regenerated in two different ways in vivo.
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