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  • Title: Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa.
    Author: Lazarova TI, Jin L, Rynkiewicz M, Gorga JC, Bibbins F, Meyers HV, Babine R, Strickler J.
    Journal: Bioorg Med Chem Lett; 2006 Oct 01; 16(19):5022-7. PubMed ID: 16876411.
    Abstract:
    A series of functionalized aryl boronic acids were synthesized and evaluated as potential inhibitors of factor XIa. Crystal structures of the protein-inhibitor complexes led to the design and synthesis of second generation compounds showing single digit micromolar inhibition against FXIa and selectivity against thrombin, trypsin, and FXa.
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