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  • Title: Do some tyrosine hydroxylase-immunoreactive neurons in the human ventrolateral arcuate nucleus and globus pallidus produce only L-dopa?
    Author: Komori K, Fujii T, Nagatsu I.
    Journal: Neurosci Lett; 1991 Dec 09; 133(2):203-6. PubMed ID: 1687756.
    Abstract:
    The presence of 'tyrosine hydroxylase (TH)-only'-immunoreactive (IR) neurons is reported for the first time in the human hypothalamic region and basa ganglia, using immunohistochemical technique. 'TH-only'-IR neurons were demonstrated in the ventrolateral part of the arcuate nucleus and medial segment of globus pallidus. These neurons lacked aromatic L-amino acid decarboxylase (AADC)-, dopamine-beta-hydroxylase (DBH)-, and dopamine (DA)-immunoreactivity. The above results suggest that these 'TH-only'-IR neurons are not dopaminergic, and possibly contain L-DOPA as an end-product.
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