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  • Title: [Effects of afobazole on the BDNF content in brain structures of inbred mice with different phenotypes of emotional stress reaction].
    Author: Seredin SB, Melkumian DS, Val'dman EA, Iarkova MA, Seredina TC, Voronin MV, Lapitskaia AS.
    Journal: Eksp Klin Farmakol; 2006; 69(3):3-6. PubMed ID: 16878488.
    Abstract:
    Changes in the BDNF content in brain structures--hippocampus, hypothalamus, striatum, and frontal cortex--were determined in mice of different emotional-stress reaction phenotypes, which were subjected to emotional stress and treated by the selective anxiolytic afobazole. The changes were different in BALB/c and C57BL/6 mice. Afobazole exhibited a significant protector action against a decrease in the brain BDNF level caused by emotional stress in BALB/c mice.
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