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  • Title: A born-type approximation method for bioluminescence tomography.
    Author: Cong W, Durairaj K, Wang LV, Wang G.
    Journal: Med Phys; 2006 Mar; 33(3):679-86. PubMed ID: 16878571.
    Abstract:
    In this paper, we present a Born-type approximation method for bioluminescence tomography (BLT), which is to reconstruct an internal bioluminescent source from the measured bioluminescent signal on the external surface of a small animal. Based on the diffusion approximation for the photon propagation in biological tissue, this BLT method utilizes the Green function to establish a linear relationship between the measured bioluminescent signal and the internal bioluminescent source distribution. The Green function can be modified to describe a heterogeneous medium with an arbitrary boundary using the Born approximation. The BLT reconstruction is formulated in a linear least-squares optimization framework with simple bounds constraint. The performance of this method is evaluated in numerical simulation and phantom experiments.
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