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  • Title: Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety.
    Author: Karthikeyan MS, Prasad DJ, Poojary B, Subrahmanya Bhat K, Holla BS, Kumari NS.
    Journal: Bioorg Med Chem; 2006 Nov 15; 14(22):7482-9. PubMed ID: 16879972.
    Abstract:
    A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base (4 and 5) was prepared from triazole Schiff bases (3) by aminomethylation with formaldehyde and secondary/substituted primary amines. All newly synthesized compounds were screened for their antimicrobial activity. Compounds 3c, 4c, 4e and 4f exhibited promising antibacterial and compounds 3c, 5c, 5e and 5f showed good antifungal activity.
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