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  • Title: In vitro activity of a new antibacterial rhodanine derivative against Staphylococcus epidermidis biofilms.
    Author: Gualtieri M, Bastide L, Villain-Guillot P, Michaux-Charachon S, Latouche J, Leonetti JP.
    Journal: J Antimicrob Chemother; 2006 Oct; 58(4):778-83. PubMed ID: 16880176.
    Abstract:
    OBJECTIVES: Staphylococcus epidermidis biofilms form at the surface of implants and prostheses and are responsible for the failure of many antibiotic therapies. Only a few antibiotics are relatively active against biofilms, and rifampicin, a transcription inhibitor, is among the most effective molecules for treating biofilm-related infections. Having recently selected a new potential transcription inhibitor, we attempted to evaluate its efficacy against S. epidermidis biofilms. METHODS: Biofilm-forming S. epidermidis strains were grown planktonically or as biofilms and their susceptibility to this transcription inhibitor was compared with reference antibiotics with different mechanisms of action. CONCLUSIONS: Our results demonstrate that this new molecule is active; its effects are fast and kinetically related to those of rifampicin, but unlike rifampicin it does not select for resistant bacteria.
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