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  • Title: Synthesis of homoallylic amines via the palladium-catalyzed decarboxylative coupling of amino acid derivatives.
    Author: Burger EC, Tunge JA.
    Journal: J Am Chem Soc; 2006 Aug 09; 128(31):10002-3. PubMed ID: 16881615.
    Abstract:
    Protected homoallylic amines are synthesized by the decarboxylative coupling of alpha-amino acid derivatives. The catalytic C-C bond-forming reaction relies on the bioinspired decarboxylative metalation of alpha-amino acids to produce alpha-amino anion equivalents. The alpha-amino anion equivalents are intercepted by pi-allyl palladium electrophiles to produce substituted homoallylic amines.
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