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  • Title: Treatment of acute post-surgical infection of joint arthroplasty.
    Author: Soriano A, García S, Bori G, Almela M, Gallart X, Macule F, Sierra J, Martínez JA, Suso S, Mensa J.
    Journal: Clin Microbiol Infect; 2006 Sep; 12(9):930-3. PubMed ID: 16882303.
    Abstract:
    The best antibiotic regimen for acute prosthetic joint infection, treated without removal of the implant, has not been well-defined. This study describes the use of a protocol based on oral rifampicin combinations to treat 47 cases that were followed prospectively for a 2-year period. The regimen used most commonly was levofloxacin 500 mg/24 h plus rifampicin 600 mg/24 h for a mean duration of 2.7 +/- 1 months. The cure rate was 76.9%, and the only independent risk-factor associated with treatment failure was infection caused by methicillin-resistant Staphylococcus aureus or Enterococcus spp. (OR 17.6, p 0.003). Overall, the results suggested that use of oral antibiotics, including rifampicin, for 2-3 months was a good treatment option.
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