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  • Title: [Disequilibrium linkage between the polymorphism in exons 2, 3 and 4 of the MICA gene and HLA-B antigen of patient with ankylosing spondylitis].
    Author: Su H, Wang BL, Zhang XJ, Hao JH, Xiao Q, Ye DQ.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2006 Aug; 23(4):446-8. PubMed ID: 16883538.
    Abstract:
    OBJECTIVE: To investigate the association between the exons 2 to 4 of the MICA gene and ankylosing spondylitis (AS). METHODS: By PCR-SSOP, DNA samples from 56 AS patients and 112 random healthy individuals, as normal control were genotyped to analyse the polymorphism in exons 2, 3, 4 of the MICA alleles. RESULTS: MICA*008 was dominant in MICA allele,accounted for 32.14% and 30.36% in AS patients and normal controls respectively. The frequency of MICA*007 was significantly increased in AS patients, when compared with normal controls (chi-square=10.18, P<0.05, RR=2.50). No difference was found in the other MICA alleles. The haplotype analysis revealed that there were the strong linkage disequilibrium between MICA and HLA-B of AS patients, and normal controls. There was a difference in MICA*007-B27 between two groups (chi-square=18.46, P<0.05, RR=7.47). Both HLA-B27 and MICA*007 were strongly associated with AS. Stratified analysis showed that HLA-B27 was significantly relative to AS,while it was not found between MICA*007 and AS. CONCLUSION: The increased frequency of MICA alleles may be due to its strong linkage disequilibrium with HLA-B27.
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