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  • Title: [The measuring of ECP and IgE in middle ear effusion of patients with otitis media of effusion].
    Author: Tian J, Lu H, Liu Y, Sun C, Xue H, Meng W, Liu H.
    Journal: Lin Chuang Er Bi Yan Hou Ke Za Zhi; 2006 May; 20(10):449-50, 453. PubMed ID: 16883790.
    Abstract:
    OBJECTIVE: To study the relationship between otitis media of effusion (OME) and allergy by investigating eosinophil cationic protein in middle ear effusion ( MECP), middle ear effusion IgE (MIgE) and serum eosinophil cationic protein (SECP). METHOD: The specimens drawn from 31 patients of OME were tested with Uni-CAP-100 allergic antigen testing system for the MECP, IgE and SECP. The results then were analyzed by statistical methods. RESULT: MECP were found in all the effusion specimens of 31 patients, the average concentration of which was 56.88 microg/L. The MECP concentration level in nine specimens (28.1%) was significantly elevated. The average concentration of MIgE was 27.2 ku/L. The MIgE concentration level in three specimens (9.7%) was remarkably increased. There was a positive correlation between the MECP level and the MIgE level( P <0.05). The average concentration of SECP was 5.6 microg/L. CONCLUSION: ECP exists in the middle ear effusion of OME. OME is an allergic inflammatory process more localized in middle ear itself in some patients. There may be a complicated allergic mechanism in OME.
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