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  • Title: [Serotonin transporter gene polymorphism in slow transit constipation].
    Author: Ding JH, Fu CG, Zhao RH, Meng RG.
    Journal: Zhonghua Wei Chang Wai Ke Za Zhi; 2006 Jul; 9(4):328-30. PubMed ID: 16886116.
    Abstract:
    OBJECTIVE: To investigate the association between the polymorphism of serotonin transporter gene-linked polymorphic region(5-HTTLPR) and slow transit constipation(STC). METHODS: Polymerase chain reaction was used to assess 5-HTTLPR polymorphism of SERT gene in 54 patients with STC and 100 healthy controls. RESULTS: The frequencies of serotonin transporter short/short(S/S) and allele S genotypes were significantly higher in STC patients than those in controls(72.2% vs 50.0%; 83.3% vs 72.5%; both P< 0.05). There were no significant differences in 5-HTTLPR polymorphism respectively between the two groups according to gender and age(less than 45 and more than 45 years old). The frequency of S/S genotype was higher in the patients with less than 40% of the ingested markers evacuated within 72 h than those with more than 40% evacuated(71.7% vs 42.6%, P< 0.05). CONCLUSION: The presence of 5-HTTLPR allele S may contribute to the pathogenesis of STC.
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