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  • Title: Subcellular localization of pulmonary antiotensin-converting enzyme (kininase II).
    Author: Ryan JW, Ryan US, Schultz DR, Whitaker C, Chung A.
    Journal: Biochem J; 1975 Feb; 146(2):497-9. PubMed ID: 168877.
    Abstract:
    Goat antibodies to pig lung angiotensin-converting enzyme (kininase II) were conjugated to microperoxidase. Rat lung tissue, previously incubated with non-immune goat serum, was incubated with the antibody-microperoxidase conjugate and then with H2O2 and 3,3-diaminobenzidine. Electron microscopy revealed reaction product on the plasma membrane and caveolae of endothelial cells, especially those of capillaries and venules. These results support the hypothesis that angiotensin I and bradykinin are metabolized by enzymes on the luminal surface of pulmonary endothelial cells.
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