These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Can PACAP-38 modulate immune and endocrine responses during lipopolysaccharide (LPS)-induced acute inflammation?
    Author: Baranowska-Bik A, Bik W, Wolinska-Witort E, Chmielowska M, Martynska L, Baranowska B.
    Journal: Ann N Y Acad Sci; 2006 Jul; 1070():156-60. PubMed ID: 16888158.
    Abstract:
    Pituitary adenylate cyclase-activating polypeptide (PACAP) shows a potential anti-inflammatory activity and interacts with the endocrine system. The aim of the present article was to evaluate the effects of PACAP38 on the endocrine and immune systems during acute inflammation. Rats used in the experiments, divided into four groups, were given intraperitoneal injection of, respectively 0.9% NaCl, LPS, PACAP38, and LPS+PACAP38. Hormone (pituitary, adrenal, and thyroid) and cytokine (TNF-alpha, IL-6, IL10) concentrations were measured 2 and 4 h after the injection. Treatment with LPS + PACAP, as compared to LPS, caused TNF-alpha and corticosterone to decrease and T4 to increase after 2 h. These data suggest that PACAP modulates both the endocrine and immune responses in this model of septic shock.
    [Abstract] [Full Text] [Related] [New Search]