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  • Title: [Features of a cytokine profile in patients with chronic glomerulonephritis with progressive chronic renal failure].
    Author: Koriakova NN, Rozhdestvenskaia ED, Kazantseva SV, Bushueva TV, Valamina IE.
    Journal: Ter Arkh; 2006; 78(5):14-7. PubMed ID: 16889043.
    Abstract:
    AIM: To specify the cytokine profile in chronic glomerulonephritis (CGN) with aggravating renal function, to assess prognostic value of some cytokines in development of CGN in these patients. MATERIAL AND METHODS: Indices of the cytokine profile were followed up in 56 CGN patients with nephrotic syndrome and arterial hypertension and compared in those patients who developed CGN for 2 years (group 2) versus patients with intact renal function (group 1). RESULTS: Serum levels of IL-1beta and TNF-alpha were maximal in CGN patients with aggravating renal function. Such patients had a low concentration of serum IL-1beta receptors antagonists. Severity of proteinurea correlated with serum level of TNF-alpha. If the latter was higher than 120 pg/ml, there was a high probability of CRF development within 2 years. CONCLUSION: Pathogenesis of CRF in CGN is associated with proinflammatory cytokines, especially TNF-alpha. Its serum concentration can be used for evaluating risk of renal function deterioration.
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