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  • Title: [Comparison of melatonin receptor mRNA expression in bilateral paravertebral muscles in adolescent idiopathic scoliosis].
    Author: Qiu Y, Wu L, Wang B, Yu Y, Zhu ZZ, Qian BP, Ma WW.
    Journal: Zhonghua Wai Ke Za Zhi; 2006 Jun 15; 44(12):826-9. PubMed ID: 16889730.
    Abstract:
    OBJECTIVE: To study the change of melatonin receptor mRNA expression in paravertebral muscles in adolescent idiopathic scoliosis (AIS), and analyze its relationship with the etiology of AIS. METHODS: Twenty cases with average age of (15.1 +/- 2.2) years and average Cobb angle of 56 degrees +/- 16 degrees , including 10 cases with Cobb angle > 50 degrees and 10 cases with Cobb angle <or= 50 degrees , were in AIS group. The apical vertebrae were from T(6 - 11). Twelve cases with average age of (11.6 +/- 3.2) years and average Cobb angle of 59 degrees +/- 33 degrees were in congenital scoliosis (CS) group. The apical vertebrae were from T(7 - 12). Ten cases without scoliosis were in control group. The mRNA expression of melatonin receptor subtype MT1 and MT2 were detected by RT-PCR method. RESULTS: The MT2 mRNA expression of paravertebral muscles on concave side was higher than that on convex side in AIS and CS groups (P < 0.05), but the MT1 mRNA expression showed no significant difference (P > 0.05). In AIS group, the ratio of MT2 mRNA expression on concave side compared with convex side in cases with Cobb angle > 50 degrees and cases with Cobb angle <or= 50 degrees showed no significant difference (P > 0.05). The MT1 and MT2 mRNA expression showed no significant difference in control group (P > 0.05). CONCLUSIONS: The melatonin receptor expression in bilateral paravertebral muscles in AIS is asymmetric, which may be a secondary change and has no important role in the pathogenesis of AIS.
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