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  • Title: Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.
    Author: Sasikumar TK, Qiang L, Burnett DA, Greenlee WJ, Hawes BE, Kowalski TJ, O'Neill K, Spar BD, Weig B.
    Journal: Bioorg Med Chem Lett; 2006 Oct 15; 16(20):5427-31. PubMed ID: 16889961.
    Abstract:
    A series of novel aminobenzimidazoles was prepared and evaluated for h-MCH-R1 antagonist properties. Most of the compounds showed excellent h-MCH-R1 binding affinity as well as mouse ex vivo binding. Compounds 9 and 18 were active in mouse DIO studies at 30mpk.
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