These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Auditory perception and attention as reflected by the brain event-related potentials in children with Asperger syndrome.
    Author: Lepistö T, Silokallio S, Nieminen-von Wendt T, Alku P, Näätänen R, Kujala T.
    Journal: Clin Neurophysiol; 2006 Oct; 117(10):2161-71. PubMed ID: 16890012.
    Abstract:
    OBJECTIVE: Language development is delayed and deviant in individuals with autism, but proceeds quite normally in those with Asperger syndrome (AS). We investigated auditory-discrimination and orienting in children with AS using an event-related potential (ERP) paradigm that was previously applied to children with autism. METHODS: ERPs were measured to pitch, duration, and phonetic changes in vowels and to corresponding changes in non-speech sounds. Active sound discrimination was evaluated with a sound-identification task. RESULTS: The mismatch negativity (MMN), indexing sound-discrimination accuracy, showed right-hemisphere dominance in the AS group, but not in the controls. Furthermore, the children with AS had diminished MMN-amplitudes and decreased hit rates for duration changes. In contrast, their MMN to speech pitch changes was parietally enhanced. The P3a, reflecting involuntary orienting to changes, was diminished in the children with AS for speech pitch and phoneme changes, but not for the corresponding non-speech changes. CONCLUSIONS: The children with AS differ from controls with respect to their sound-discrimination and orienting abilities. SIGNIFICANCE: The results of the children with AS are relatively similar to those earlier obtained from children with autism using the same paradigm, although these clinical groups differ markedly in their language development.
    [Abstract] [Full Text] [Related] [New Search]