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  • Title: Seven-transmembrane receptor signalling and ERK compartmentalization.
    Author: Caunt CJ, Finch AR, Sedgley KR, McArdle CA.
    Journal: Trends Endocrinol Metab; 2006 Sep; 17(7):276-83. PubMed ID: 16890451.
    Abstract:
    Vast numbers of extracellular signalling molecules exert effects on their target cells by activation of a relatively limited number of mitogen-activated protein kinase (MAPK) cascades, raising the question of how specificity is achieved. To a large extent, this appears to be attributable to differences in kinetics and compartmentalization of MAPK protein activation that are dictated by MAPK-associated proteins serving as scaffolds, anchors, activators or effectors. Here, we review spatiotemporal aspects of signalling via the Ras-Raf-extracellular signal-regulated kinase pathway, emphasizing recent work on roles of arrestins as scaffolds and transducers for seven transmembrane receptor signalling.
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